TRF2 is in neuroglial cytoplasm and induces neurite‐like processes

FEBS Letters

Bang, Seunghyun¹  Song, Kyuyoung⁴  Lee, Inchul²  Kim, Soonok¹  Lee, Seungku¹  Lee, Changhee¹  Choi, Kyungho¹  Kim, Chong Jai³  Lee, Seong-Gene¹  Jung, Yusun¹ 

[1] Asan Institute for Life Sciences, University of Ulsan College of Medicine, 388-1 Poongnap-dong, Songpa-Gu, Seoul 138-736, South Korea;Department of Pathology, University of Ulsan College of Medicine, 388-1 Poongnap-dong, Songpa-Gu, Seoul 138-736, South Korea;Department of Pathology, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-799, South Korea;Department of Biochemistry, University of Ulsan College of Medicine, 388-1 Poongnap-dong, Songpa-Gu, Seoul 138-736, South Korea

关键词: TRF2;    Neural differentiation;    Glia;    Axon;    Neurite;    TRF2;    TTAGGG repeat binding factor 2;   

DOI  :  10.1016/S0014-5793(03)01461-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

TRF2 is a ubiquitous protein that protects telomeres in the nucleus. We found that TRF2 was present at the peripheral nerve axons and the brain neuroglial cell processes extensively. It was in the cytoplasmic membrane as well as nuclear fractions, but not in the soluble cytoplasmic fraction of SH-SY5Y neuroblastoma cells. TRF2 was up-regulated in P19 embryonal carcinoma cells at the early stage of induced neural differentiation with retinoic acid treatment. Upon transfection, TRF2-expressing COS cells often produced neurite-like long cytoplasmic processes. TRF2 is a component of neuroglial cells and appears to be involved in the cytoplasmic process formation that is necessary for neural differentiation.

【 授权许可】

Unknown