Transcription‐coupled TA and GC strand asymmetries in the human genome

FEBS Letters

Nicolay, S¹  Thermes, C²  Touchon, M²  d'Aubenton-Carafa, Y²  Arneodo, A¹ 

[1] Laboratoire de Physique, Ecole Normale Supérieure de Lyon, 69364 Lyon, France;Centre de Génétique Moléculaire, CNRS, Allée de la Terrasse, 91198 Gif-sur-Yvette, France

关键词: Skewness;    Strand asymmetry;    Mutation bias;    Human genome;   

DOI  :  10.1016/S0014-5793(03)01306-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Analysis of the whole set of human genes reveals that most of them present TA and GC skews, that these biases are correlated to each other and are specific to gene sequences, exhibiting sharp transitions between transcribed and non-transcribed regions. The GC asymmetries cannot be explained solely by a model previously proposed for (G+T) skew based on transitions measured in a small set of human genes. We propose that the GC skew results from additional transcription-coupled mutation process that would include transversions. During evolution, both processes acting on a large majority of genes in germline cells would have produced these transcription-coupled strand asymmetries.

【 授权许可】

Unknown