Polyhalogenated benzo‐ and naphthoquinones are potent inhibitors of plant and bacterial ureases

FEBS Letters

Kleiner, Diethelm¹  Ashiralieva, Ainura¹ 

[1] Mikrobiologie, Universität Bayreuth, 95440 Bayreuth, Germany

关键词: Urease;    Enzyme inhibition;    Quinone;    Fluoranil;    Chloranil;    Bromanil;   

DOI  :  10.1016/S0014-5793(03)01289-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Polyhalogenated benzo- and naphthoquinones were found to be potent inhibitors of pure ureases from Bacillus pasteurii and Canavalia ensiformis. They also inhibited ureases in whole cells of Helicobacter pylori, Klebsiella oxytoca and Proteus mirabilis. Inhibition was non-competitive with K _i values in the micromolar range or below. Inhibition was irreversible as shown by equilibrium dialysis. Inhibitory power decreased considerably when halogens were replaced by –OH, –CN, alkoxy or alkyl groups.

【 授权许可】

Unknown