Involvement of gicerin, a cell adhesion molecule, in development and regeneration of chick sciatic nerve

FEBS Letters

Hiroi, Satoshi²  Taira, Eiichi¹  Tsukamoto, Yasuhiro²  Sasaki, Fumihiko²  Miki, Naomasa¹ 

[1] Department of Pharmacology 1, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan;Department of Veterinary Anatomy, Osaka Prefecture University, Graduate School of Agriculture and Biological Sciences, 1-1 Gakuencho, Sakai, Osaka 599-8531, Japan

关键词: Gicerin;    Cell adhesion molecule;    Sciatic nerve;    Development;    Regeneration;    Neurite outgrowth factor;   

DOI  :  10.1016/S0014-5793(03)01176-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have examined the role of gicerin, an immunoglobulin superfamily cell adhesion molecule, in chick sciatic nerves during development and regeneration. Gicerin was expressed in the spinal cord, dorsal root ganglion (DRG) and sciatic nerves in embryos, but declined after hatching. Neurite extensions from explant cultures of the DRG were promoted on gicerin's ligands, which were inhibited by an anti-gicerin antibody. Furthermore, gicerin expression was upregulated in the regenerating sciatic nerves, DRG and dorsal horn of the spinal cord after injury to the sciatic nerve. These results indicate that gicerin might participate in the development and regeneration of sciatic nerves.

【 授权许可】

Unknown