期刊论文详细信息
FEBS Letters | |
Inhibition of influenza A virus sialidase activity by sulfatide | |
Fujii, Satoshi1  Miyamoto, Daisei2  Murakami, Masanori1  Suzuki, Takashi2  Suzuki, Yasuo2  Hidari, Kazuya I.-P.Jwa2  Li, Yu-Teh3  Nishinaka, Daisuke2  Takahashi, Tadanobu2  | |
[1] Department of Physical Chemistry, University of Shizuoka, School of Pharmaceutical Sciences, Shizuoka 422-8526, Japan;Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, CREST, JST, and COE Program in the 21st Century, Shizuoka 422-8526, Japan;Department of Biochemistry, Tulane University School of Medicine, New Orleans, LA 70112, USA | |
关键词: Sulfatide; Sialidase; Influenza virus; Neuraminidase; Inhibitor; 4G-Neu5Ac2en; 4-guanidino-2-deoxy-2; 3-didehydro-N-acetyl-D-neuraminic acid; HA; hemagglutinin; MDCK; Madin–Darby canine kidney; 4-MU-Neu5Ac; 2′-(4-methylumbelliferyl)-α-D-N-acetylneuraminic acid; 4-MU; 4-methylumbelliferone; NA; neuramindase; Neu5Ac2en; 2-deoxy-2; 3-didehydro-N-acetyl-D-neuraminic acid; | |
DOI : 10.1016/S0014-5793(03)01045-7 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Sulfatide, which binds to influenza A viruses and prevents the viral infection, was found to inhibit the sialidase activities of influenza A viruses in a pH-dependent manner. The kinetic parameters of the effect of sulfatide on the sialidase activities of human influenza A viruses using fluorometric assay indicated that sulfatide was a powerful and non-competitive type inhibitor in low-pH conditions.
【 授权许可】
Unknown
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