2‐Cyclopenten‐1‐one and prostaglandin J2 reduce restenosis after balloon angioplasty in rats: role of NF‐κB

FEBS Letters

Cuzzocrea, Salvatore¹  Di Rosa, Massimo³  Mazzon, Elena²  Ialenti, Armando³  Ianaro, Angela³  Maffia, Pasquale³  Santoro, Maria Gabriella⁴ 

[1] Institute of Pharmacology, University of Messina, Messina, Italy;Department of Biomorphology, School of Medicine, University of Messina, Messina, Italy;Department of Experimental Pharmacology, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy;Department of Biology, University of Rome Tor Vergata, Rome, Italy

关键词: Cyclopentenone prostaglandin;    2-Cyclopenten-1-one;    Nuclear factor-κB;    Restenosis;    cyPG;    cyclopentenone prostaglandin;    EMSA;    electrophoretic mobility shift assay;    IKK;    I-κB kinase;    ICAM-1;    intercellular adhesion molecule-1;    IEL;    internal elastic lamina;    L-PDGS;    lipocalin-type prostaglandin D synthase;    NF-κB;    nuclear factor-κB;    PTCA;    percutaneous transluminal coronary angioplasty;    PPARγ;    peroxisome proliferator-activated receptor-γ;    VSMC;    vascular smooth muscle cell;   

DOI  :  10.1016/S0014-5793(03)00873-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The aim of this study was to evaluate, using a rat model of balloon angioplasty, whether prostaglandin (PG) J₂ and 2-cyclopenten-1-one are able to reduce restenosis. We found that both PGJ₂ and 2-cyclopenten-1-one, administered by local application on carotid arteries, caused a dose-dependent inhibition of neointimal formation. Furthermore, both agents prevented vascular negative remodeling. The effect of these compounds on restenosis was correlated with an inhibition of nuclear factor-κB (NF-κB) activation as well as of intercellular adhesion molecule-1 (ICAM-1) protein expression in injured carotid arteries of control animals. Our results show that cyclopentenone PGs and their derivatives reduce restenosis and may have therapeutic relevance for the prevention of human restenosis.

【 授权许可】

Unknown