Unravelling the activation mechanisms of protein kinase B/Akt

FEBS Letters

Scheid, Michael P.¹  Woodgett, James R.¹ 

[1] Ontario Cancer Institute, 610 University Avenue, Toronto, ON, Canada M5G 2M9

关键词: Protein kinase;    Signal transduction;    Protein kinase B;    Akt;    3-Phosphoinositide-dependent kinase-1;    Phosphatidylinositol 3-kinase;    PKB;    protein kinase B;    PI3K;    phosphoinositide 3-kinase;    PDK1;    3-phosphoinositide-dependent kinase-1;    PH domain;    pleckstrin homology domain;    HM;    hydrophobic motif;    PIF;    PRK2-interacting fragment;   

DOI  :  10.1016/S0014-5793(03)00562-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Over the past decade, protein kinase B (PKB, also termed Akt) has emerged as an important signaling mediator between extracellular cues and modulation of gene expression, metabolism, and cell survival. The enzyme is tightly controlled and consequences of its deregulation include loss of growth control and oncogenesis. Recent work has better characterized the mechanism of PKB activation, including upstream regulators and secondary binding partners. This minireview refreshes some old concepts with new twists and highlights current outstanding questions.

【 授权许可】

Unknown