NDR family of AGC kinases – essential regulators of the cell cycle and morphogenesis

FEBS Letters

Bichsel, Samuel J.¹  Tamaskovic, Rastislav¹  Hemmings, Brian A.¹ 

[1] Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland

关键词: NDR;    LATS;    AGC group;    Protein kinase;    Morphogenesis;    Cell cycle;    CaM;    calmodulin;    CDK;    cyclin-dependent kinase;    GAP;    GTPase-activating protein;    GTPase;    guanosine 5′-triphosphate-binding protein;    MEN;    mitotic exit network;    SIN;    septation initiation network;    SMA;    S100B and Mob1 association;    SPB;    spindle pole body;   

DOI  :  10.1016/S0014-5793(03)00474-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The nuclear Dbf2-related (NDR) family of protein serine/threonine kinases comprises mammalian NDR and large tumor suppressor (LATS) kinases, their orthologs from Drosophila melanogaster and Caenorhabditis elegans, and a number of related kinases from yeast and plants. The members of this family were independently implicated in various aspects of the control of cell division and morphogenesis. They are crucial regulators of the actin and tubulin cytoskeletal organization during polarized growth and cytokinesis in yeast. Furthermore, they are key players in control of proliferation and morphology of many cell types in D. melanogaster and C. elegans. In mammalians, the LATS kinase is a tumor suppressor, negatively regulating the cyclin-dependent kinase CDK1, cell proliferation rate, and modulating cell survival.

【 授权许可】

Unknown