Update on estrogen signaling

FEBS Letters

Cheng, Guojun¹  Andersson, Sandra¹  Weihua, Zhang¹  Warner, Margaret¹  Gustafsson, Jan-Åke¹  Simpson, Evan R.² 

[1] Department of Medical Nutrition, Department of Biosciences, Karolinska Institute, NOVUM, S-141 86 Huddinge, Sweden;Prince Henry's Institute of Medical Research, Clayton, Vic. 3168, Australia

关键词: Estrogen receptor;    Estrogen;    Breast cancer;    Prostate;    Central nervous system;    E2;    17β-estradiol;    ER;    estrogen receptor;    DBD;    DNA binding domain;    LBD;    ligand binding domain;    AF;    activation function;    ERE;    estrogen response element;    ER−/−;    estrogen receptor knockout;    wt;    wild type;    SRC;    steroid receptor coactivator;    Ar;    aromatase;    DHT;    5α-dihydrotestosterone;    3βAdiol;    5α-androstane-3β;    17β-diol;    HSD;    hydroxysteroid dehydrogenase;    PR;    progesterone receptor;   

DOI  :  10.1016/S0014-5793(03)00436-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Our understanding of estrogen signaling has undergone a true paradigm shift over recent years, following the discovery in 1995 of a second estrogen receptor, estrogen receptor β (ERβ). In many contexts ERβ appears to antagonize the actions of ERα (yin/yang relationship) although there also exist genes that are specifically regulated by one of the two receptors. Studies of ERβ knockout mice have shown that ERβ exerts important functions in the ovary, central nervous system, mammary gland, prostate gland, hematopoiesis, immune system, vessels and bone. The use of ERβ-specific ligands against certain forms of cancer represents one of the many pharmaceutical possibilities that have been created thanks to the discovery of ERβ.

【 授权许可】

Unknown