Growth phase‐dependent changes in the subcellular localization of pre‐B‐cell colony‐enhancing factor 1

FEBS Letters

Fujisawa, Hitoshi¹  Okuno, Sachiko¹  Kitani, Takako¹ 

[1] Department of Biochemistry, Asahikawa Medical College, Asahikawa 078-8510, Japan

关键词: Pre-B-cell colony-enhancing factor;    Cell cycle;    Subcellular distribution;    Cell nucleus;    PBEF;    pre-B-cell colony-enhancing factor;   

DOI  :  10.1016/S0014-5793(03)00476-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A cDNA encoding the homolog of the human pre-B-cell colony-enhancing factor (PBEF), a cytokine-like secreted protein, was isolated from a rat cDNA library. This protein existed in both the cytoplasm and nucleus of the cells, and the amount was higher in the cytoplasm than in the nucleus of proliferating PC-12 and Swiss 3T3 cells but higher in the nucleus than in the cytoplasm of the PC-12 cells treated with nerve growth factor and the 3T3 cells grown to a confluent state. Thus, the so-called PBEF is not a cytokine-like secreted protein but an intracellular protein associated with the cell cycle.

【 授权许可】

Unknown