Plant polyphenols inhibit VacA, a toxin secreted by the gastric pathogen Helicobacter pylori

FEBS Letters

Del Giudice, Giuseppe¹  Tombola, Francesco²  Zoratti, Mario²  Campello, Silvia²  Papini, Emanuele²  Ruggiero, Paolo¹  De Luca, Laura² 

[1] Immunobiology Research Institute Siena, CHIRON S.p.A., Via Fiorentina 1, 53100 Siena, Italy;CNR Institute of Neurosciences, Biomembranes section, and Department of Biomedical Sciences, University of Padova, Viale G. Colombo 3, 35121 Padua, Italy

关键词: VacA;    Gastritis;    Polyphenol;    Flavone;    Green tea;    Helicobacter pylori;   

DOI  :  10.1016/S0014-5793(03)00443-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

VacA is a major virulence factor of the widespread stomach-dwelling bacterium Helicobacter pylori. It causes cell vacuolation and tissue damage by forming anion-selective, urea-permeable channels in plasma and endosomal membranes. We report that several flavone derivatives and other polyphenols present in vegetables and plants inhibit ion and urea conduction and cell vacuolation by VacA. Red wine and green tea, which contain many of the compounds in question, also potently inhibit the toxin. These observations suggest that polyphenols or polyphenol derivatives may be useful in the prevention or cure of H. pylori-associated gastric diseases.

【 授权许可】

Unknown