IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton

FEBS Letters

Briggs, Michael W¹  Sacks, David B¹ 

[1] Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Thorn 530, 75 Francis Street, Boston, MA 02115, USA

关键词: Cytoskeleton;    Rho GTPase;    Calcium;    Calmodulin;    Cytokinesis;   

DOI  :  10.1016/S0014-5793(03)00333-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A family of proteins known as IQGAPs have been identified in yeast, amebas and mammals. IQGAPs are multidomain molecules that contain several protein-interacting motifs which mediate binding to target proteins. Mammalian IQGAP1 is a component of signaling networks that are integral to maintaining cytoskeletal architecture and cell–cell adhesion. Published data suggest that IQGAP1 is a scaffolding protein that modulates cross-talk among diverse pathways in complex regulatory circuits. These pathways include modulating the actin cytoskeleton, mediating signaling by Rho family GTPases and calmodulin, regulating E-cadherin and β-catenin function and organizing microtubules.

【 授权许可】

Unknown