Enhanced plasma ghrelin levels in rats with streptozotocin‐induced diabetes

FEBS Letters

Ota, Takayuki¹  Minegishi, Yuriko⁴  Kangawa, Kenji³  Nagata, Hiroshi²  Suzuki, Hidekazu²  Masaoka, Tatsuhiro²  Ishii, Hiromasa²  Hosoda, Hiroshi³ 

[1]Department of Dermatology, School of Medicine, Keio University, Tokyo, Japan

[2]Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan

[3]Department of Biochemistry, National Cardiovascular Center Research Institute, Osaka, Japan

[4]Center for Integrated Medical Research, School of Medicine, Keio University, Tokyo, Japan

关键词: Preproghrelin;    Ghrelin;    Diabetes;    Stomach;    Growth hormone;   

DOI  :  10.1016/S0014-5793(03)00306-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Ghrelin is a novel gastrointestinal peptide that stimulates growth hormone secretion, food intake, and body weight gain. Increased ghrelin secretion has been reported in such negative energy states as starvation and low body weight. We investigated the dynamics of ghrelin in rats with streptozotocin-induced diabetes, because they present reduced body weight and hyperphagia. The plasma ghrelin levels and gastric preproghrelin mRNA expression levels of the diabetic rats increased significantly and their gastric ghrelin levels decreased significantly. Negative energy balance may enhance preproghrelin mRNA expression and ghrelin secretion into the bloodstream.

【 授权许可】

Unknown