Identification of mammalian orthologs associates PYPAF5 with distinct functional roles

FEBS Letters

Lengauer, Thomas¹  Albrecht, Mario¹  Schreiber, Stefan²  Domingues, Francisco S.¹ 

[1] Max-Planck-Institute for Informatics, Stuhlsatzenhausweg 85, 66123 Saarbrücken, Germany;First Department of Medicine, Christian-Albrechts-Universität Kiel, Schittenhelmstr. 12, 24105 Kiel, Germany

关键词: PYRIN-/CARD-containing protein;    Mammalian ortholog;    Inflammation;    Hormone receptor;    G-protein coupled receptor;    Structure prediction;    LRR;    leucine-rich repeat;    GPCR;    G-protein coupled receptor;    AVR;    angiotensin II and arginine vasopressin receptor;    AII;    angiotensin II;    AVP;    arginine vasopressin;    RNI;    ribonuclease inhibitor;   

DOI  :  10.1016/S0014-5793(03)00161-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

PYRIN- and CARD-containing proteins belong to a recently identified protein family involved in the regulation of apoptosis and inflammatory processes. Variations in the gene products of the family members PYPAF1 and NOD2/CARD15 have been associated with several autoinflammatory diseases. We could identify the mouse orthologs of PYPAF1, PYPAF5, NOD1, NOD2 and the rat ortholog of PYPAF5. Intriguingly, we found that PYPAF5 has been reported previously not only as regulator of NF-κB and caspase-1, but also as angiotensin II and vasopressin receptor. In particular, based on a comprehensive sequence analysis, we propose a structural model for this hormone receptor that is different from the model suggested previously.

【 授权许可】

Unknown