Intramolecular rearrangements as a consequence of the dephosphorylation of phosphoaspartate residues in proteins

FEBS Letters

Stock, Jeffry B.¹  Napper, Scott³  Wolanin, Peter M.¹  Waygood, Bruce³  Webre, Daniel J.²  Kindrachuk, Jason³ 

[1] Department of Molecular Biology, Princeton University, 347 Lewis Thomas Lab, Princeton, NJ 08544, USA;Department of Chemistry, Princeton University, Princeton, NJ 08544, USA;Department of Biochemistry, Health Sciences Building, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5

关键词: Response regulator;    Phosphoaspartate;    Succinimide;    CheY;    OmpR;   

DOI  :  10.1016/S0014-5793(03)00132-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Aspartate phosphorylation induces changes in protein conformation that are used to regulate processes ranging from gene expression and cell differentiation to cell motility and the generation of electrochemical gradients across membranes. We show here that dephosphorylation of the phosphoaspartate in the chemotaxis response regulator CheY can result in the loss of a water molecule that may be due to formation of a succinimide intermediate.

【 授权许可】

Unknown