A forkhead transcription factor FKHR up‐regulates lipoprotein lipase expression in skeletal muscle

FEBS Letters

Mizukami, Junko⁴  Ezaki, Osamu¹  Miura, Shinji¹  Suzuki, Miki¹  Kamei, Yasutomi³  Kawada, Teruo²  Taniguchi, Tomoyasu⁴  Takahashi, Nobuyuki² 

[1] Division of Clinical Nutrition, National Institute of Health and Nutrition, 1-23-1, Toyama Shinjuku-ku, Tokyo 162-8636, Japan;Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan;PRESTO, Japan Science and Technology Corporation, National Institute of Health and Nutrition, 1-23-1, Toyama Shinjuku-ku, Tokyo 162-8636, Japan;Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd., Saitama, Japan

关键词: Lipoprotein lipase;    FKHR;    PPAR;    GLUT4;    SREBP;    Skeletal muscle;    LPL;    lipoprotein lipase;    PPAR;    peroxisome proliferator-activated receptor;    FAT;    fatty acid transporter;    STZ;    streptozotocin;    FKHR;    forkhead homolog in rhabdomyosarcoma;   

DOI  :  10.1016/S0014-5793(03)00062-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Lipoprotein lipase (LPL) plays a role in lipid usage in skeletal muscle by hydrolyzing plasma triglycerides into fatty acids, which are further utilized for β-oxidation. Lipid usage is stimulated during fasting, diabetes mellitus and exercise, concomitant with enhanced LPL expression in skeletal muscle. Here we show that the forkhead type transcription factor FKHR is strongly induced in skeletal muscle in fasting mice, in mice with streptozotocin-induced diabetes and in mice after treadmill running. Ectopic expression of FKHR enhanced LPL gene expression in C2C12 muscle cells in culture. These results implicate FKHR as an important modulator of lipid metabolism in skeletal muscle.

【 授权许可】

Unknown