Lymphotoxin‐β receptor mediates NEMO‐independent NF‐κB activation

FEBS Letters

Saitoh, Tatsuya¹  Yamamoto, Naoki¹  Yamaoka, Shoji¹  Nakano, Hiroyasu² 

[1] Department of Molecular Virology, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan;Department of Immunology, Graduate School of Medicine, Juntendo University, 2-1-1, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan

关键词: IκB kinase;    Lymphotoxin-β receptor;    Nuclear factor-κB essential modulator;    Nuclear factor-κB;    RelB;    EMSA;    electrophoretic mobility shift assay;    IκB;    inhibitor of NF-κB;    IKK;    IκB kinase;    IL-1β;    interleukin-1β;    LTβR;    lymphotoxin-β receptor;    LPS;    lipopolysaccharide;    MAPK;    mitogen-activated protein kinase;    MAP3K;    mitogen-activated protein kinase kinase kinase;    MEF;    mouse embryo fibroblast;    NEMO;    NF-κB essential modulator;    NF-κB;    nuclear factor-κB;    NIK;    NF-κB-inducing kinase;    TNFR;    tumor necrosis factor receptor;    TRAF;    TNFR-associated factor;   

DOI  :  10.1016/S0014-5793(02)03622-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Lymphotoxin-β receptor (LTβR) is a member of the tumor necrosis factor receptor (TNFR) superfamily that activates nuclear factor-κB (NF-κB) through the IκB kinase (IKK) complex, the core of which is comprised of IKK1, IKK2 and NF-κB essential modulator (NEMO). We demonstrate here that the LTβR signaling to NF-κB activation does not necessarily require NEMO, which is essential for TNFR signaling. In the absence of NEMO, the p50 and RelB, but not RelA subunits of NF-κB are found in the nuclear DNA binding complexes induced by the LTβR signaling. Our results thus disclose NEMO-independent NF-κB activation by LTβR.

【 授权许可】

Unknown