Insulin feedback action on pancreatic β‐cell function

FEBS Letters

Berggren, Per-Olof¹  Leibiger, Barbara¹  Leibiger, Ingo B¹ 

[1] The Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Hospital L3, Karolinska Institutet, S-171 76 Stockholm, Sweden

关键词: Insulin;    Insulin receptor;    Insulin secretion;    Gene expression;    Diabetes mellitus;   

DOI  :  10.1016/S0014-5793(02)03627-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Pancreatic β-cell function is essential for the regulation of glucose homeostasis and its impairment leads to diabetes mellitus. Besides glucose, the major nutrient factor, inputs from neural and humoral components and intraislet cell–cell communication act together to guarantee an appropriate pancreatic β-cell function. Data obtained over the last 5 years in several laboratories have revitalized a controversial concept, namely the autocrine feedback action of secreted insulin on β-cell function. While, historically, insulin was suggested to exert a negative effect on β-cells, recent data provide evidence for a positive role of insulin in transcription, translation, ion flux, insulin secretion and β-cell survival.

【 授权许可】

Unknown