Tandem genomic arrangement of a G protein (Gna15) and G protein‐coupled receptor (s1p4 /lpC1 /Edg6) gene

FEBS Letters

Contos, James J.A¹  Chun, Jerold¹  Ye, Xiaoqin¹  Sah, Valerie P¹ 

[1] Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla, CA 92093-0636, USA

关键词: Lysophospholipid;    Sphingosine;    Sphingosine-1-phosphate;    Signal transduction;    Genomics;    Mouse;   

DOI  :  10.1016/S0014-5793(02)03409-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A genomic analysis of the s1p₄ /lp_C1 /Edg6 mouse sphingosine-1-phosphate (S1P) G protein-coupled receptor gene revealed it to be located on central chromosome 10 and to consist of two exons with an intronless coding region. Surprisingly, we found the gene encoding the promiscuously coupling G_α15 protein (Gna15) located in tandem just upstream, an arrangement conserved in the human genome (on chromosome 19p13.3). Given that Northern blots demonstrated similar tissue distributions of the mouse s1p₄ and Gna15 transcripts, we propose that transcription of the two genes may be under control of the same enhancer elements and that their protein products may couple in vivo.

【 授权许可】

Unknown