Mitogen‐inducible gene 6 (MIG‐6), adipophilin and tuftelin are inducible by hypoxia

FEBS Letters

Hankinson, Oliver¹  Rivera, Steven P¹  Saarikoski, Sirkku T¹ 

[1] Department of Pathology and Laboratory Medicine, and Jonsson Comprehensive Cancer Center, University of California, P.O. Box 951732, Los Angeles, CA 90095, USA

关键词: Hypoxia;    MIG-6;    Adipophilin;    Tuftelin;    DEC1;    ARNT;    AHR;    aryl hydrocarbon receptor;    ARNT;    aryl hydrocarbon receptor nuclear translocator;    bHLH;    basic helix-loop-helix;    ChoB;    Chinese hamster ovary B;    DEC1;    differentiated embryo chondrocyte 1;    HIF-1;    hypoxia-inducible factor 1;    MIG-6;    mitogen-inducible gene 6;    PAS;    Per-Arnt-Sim;    PCR;    polymerase chain reaction;    RDA;    representational difference analysis;   

DOI  :  10.1016/S0014-5793(02)03475-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Adaptation to hypoxia is essential for tumor progression. Transcriptional activation of hypoxia-regulated genes is mediated by hypoxia-inducible factor 1 (HIF-1), a heterodimer of HIF-1α and ARNT (Ah receptor nuclear translocator; HIF-1β). Using representational difference analysis, we identified three novel hypoxia-inducible genes: MIG-6 (gene 33), adipophilin and tuftelin. The mRNAs for these genes were inducible by 1% O₂ in the human HepG2 and MCF-7 cell lines. Hypoxic induction of the MIG-6 and tuftelin proteins was also observed. Induction was ARNT-dependent. Induction also occurred in livers of mice treated with CoCl₂, which mimics hypoxia. The potential roles of these genes in adaptation to hypoxia and in tumorigenesis will be of considerable interest.

【 授权许可】

Unknown