Nucleic acid aptamers in cancer medicine

FEBS Letters

Cerchia, Laura⁴  de Franciscis, Vittorio⁴  Hamm, Jörg¹  Tavitian, Bertrand²  Libri, Domenico³ 

[1] Dipartimento di Genetica, Biologia e Biochimica, Università degli Studi di Torino, Via Santena, 5bis, I-10126 Torino, Italy;Laboratoire d’Imagerie de l’expression des gènes, CEA - SHFJ - INSERM ERITM 103, 4 place du general Leclerc, 91401 Orsay Cedex, France;Centre de Génétique Moléculaire C.N.R.S., Av de La Terrasse, 91198 Gif sur Yvette, France;Istituto per l’Endocrinologia e l’Oncologia Sperimentale del CNR ‘G. Salvatore’, via Pansini 5, 80131 Napoli, Italy

关键词: Aptamer;    Cancer;    In vivo imaging;    Oncogene;    SELEX;    Signal transduction;    RBD;    Ras-binding domain;    VEGF;    vascular endothelial growth factor;    PDGF;    platelet-derived growth factor;    bFGF;    basic fibroblast growth factor;    NES;    nuclear export signal;   

DOI  :  10.1016/S0014-5793(02)03275-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Many signalling proteins involved in diverse functions such as cell growth and differentiation can act as oncogenes and cause cellular transformation. These molecules represent attractive targets for cancer diagnosis or therapy and are therefore subject to intensive investigation. Aptamers are small nucleic acid molecules, isolated from combinatorial libraries by a procedure termed SELEX, that bind to a target molecule by providing a limited number of specific contact points embedded in a larger, defined three-dimensional structure. In some cases aptamers have the potential to inhibit the biological function of the molecule resulting in useful reagents for target validation in a variety of disease models.

【 授权许可】

Unknown