Differential regulation of transcription and induction of programmed cell death by human p53‐family members p63 and p73

FEBS Letters

Bamberger, Casimir¹  Rother, Karen²  Dietz, Sebastian²  Schmale, Hartwig¹  Mössner, Joachim²  Engeland, Kurt² 

[1] Institut für Zellbiochemie und Klinische Neurobiologie, Universität Hamburg, Martinistraße 52, D-20246 Hamburg, Germany;Medizinische Klinik und Poliklinik II, Max Bürger Forschungszentrum, Universität Leipzig, Johannisallee 30, D-04103 Leipzig, Germany

关键词: p53;    p63;    p73;    Transcription;    Apoptosis;   

DOI  :  10.1016/S0014-5793(02)03093-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The p53 tumor suppressor acts as a transcription factor and has a central function in controlling apoptosis. With p63 and p73 two genes coding for proteins homologous to p53 have been identified. We describe the properties of seven human p63 and p73 proteins as transcriptional activators of p21WAF1/CIP1 expression and apoptotic inducers in direct comparison to p53 in the same assay systems employing DLD-1-tet-off colon cells. Programmed cell death is detected in cells expressing high levels of p53 and p73α. Cells overexpressing TAp63α, TAp63γ, TA*p63α, TA*p63γ, ΔNp63α, and ΔNp63γ display low or no detectable apoptosis.

【 授权许可】

Unknown