Aldosterone augments endothelin‐1‐induced cardiac myocyte hypertrophy with the reinforcement of the JNK pathway

FEBS Letters

Oshima, Yuichi¹  Yamauchi-Takihara, Keiko¹  Funamoto, Masanobu¹  Kawase, Ichiro¹  Negoro, Shinji¹  Fujio, Yasushi¹  Izumi, Masahiro¹  Hirota, Hisao¹  Nakaoka, Yoshikazu¹ 

[1] Department of Molecular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita City, Osaka 565-0871, Japan

关键词: Aldosterone;    Hypertrophy;    Remodeling;    Signal transduction;    Endothelin-1;   

DOI  :  10.1016/S0014-5793(02)03017-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Aldosterone is thought to regulate cardiac work independently of sodium retention, though the mechanisms remain to be known. In the present study, we have demonstrated that aldosterone reinforces endothelin-mediated cardiac hypertrophy with the increase in cell surface area and upregulation of the transcripts characteristic of hypertrophy. We have also shown that aldosterone augments c-Jun N-terminal kinase activation induced by endothelin-1. Taken together, it is suggested that aldosterone modulates cardiac hypertrophy, at least partially, synergistically with extracellular signals that have been shown to be involved in cardiac remodeling.

【 授权许可】

Unknown