Myometrial maxi‐K channel β1 subunit modulation during pregnancy and after 17β‐estradiol stimulation

FEBS Letters

England, Sarah K¹  Benkusky, Nancy A¹  Brainard, Adam M¹  Korovkina, Victoria P¹ 

[1] Department of Physiology and Biophysics, 5-660 Bowen Science Building, University of Iowa, Iowa City, IA 52242, USA

关键词: Mouse;    Uterus;    Maxi-K;    β Subunit;    Gestation;    Estrogen;    Progesterone;   

DOI  :  10.1016/S0014-5793(02)03011-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Myometrial maxi-K channels are modulated by β subunits. We aimed to determine whether β subunits are modulated to affect uterine excitability during gestation. RNase protection analyses revealed that mouse β1 subunit transcripts are regulated during gestation with peak expression at day 14 of pregnancy. Immunohistochemical analysis indicates an increase of this subunit during gestation. Upregulation of the β1 transcript occurs with 4-day exposure to 17β-estradiol but not progesterone, and acute estradiol exposure has no effect on β1 transcript expression. These findings verify that β1 subunit transcript is regulated in mouse myometrium during gestation and estrogens may contribute to this increase.

【 授权许可】

Unknown