Ring up the curtain on DING proteins

FEBS Letters

Berna, Anne³  Scott, Ken¹  Bernier, François²  Stuhlmüller, Bruno¹ 

[1] Department of Rheumatology, Charite Hospital, Berlin, Germany;School of Biological Sciences, University of Auckland, Auckland, New Zealand;IBMP-Institut de Botanique, Strasbourg, France

关键词: DING protein;    Rheumatoid arthritis;    Cancer cell;    Neurone;    Phytochemical;    Biomineralisation;    Germin;    Germin-like protein;    Cell signalling;    Autoimmune disease;    DEP;    protein domain present in dishevelled;    egl-10 and pleckstrin proteins;    GLP;    germin-like protein;    HSFP;    hirudin-sensitive fibroblast proteinase;    PDZ;    protein domain found first in postsynaptic density protein and Dlg tumour suppressor;    RA;    rheumatoid arthritis;    SSP;    synovial stimulatory protein;   

DOI  :  10.1016/S0014-5793(02)03053-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

DING proteins have a characteristic DINGGG- or closely related N-terminal sequence. One is found in human synovial fluid, and may be associated with rheumatoid arthritis. Other examples have receptor or signalling roles in various human and animal cells, or are involved in biomineralisation, and several of them bind to phytochemicals. As plant DING proteins have recently been discovered, we hypothesise that the DING protein-phytochemical association may represent one aspect of a ubiquitous receptor-linked signalling system. Several microbial proteins related to DING proteins have phosphatase activity, which may relate to biomineralisation in eukaryotic systems. Plant DING proteins and their microbial relatives may elicit allergic responses leading to arthritic disease.

【 授权许可】

Unknown