The presence of 4‐hydroxyphenylacetic acid in human saliva and the possibility of its nitration by salivary nitrite in the stomach

FEBS Letters

Takahama, Umeo¹  Murata, Hideaki²  Oniki, Takayuki¹ 

[1] Kyushu Dental University, Kitakyushu 803-8580, Japan;CSC, Shimadzu, Kyoto 604-8511, Japan

关键词: 4-Hydroxyphenylacetic acid;    4-Hydroxy-3-nitrophenylacetic acid;    Nitration;    Nitrous acid;    Saliva;    HPA;    4-hydroxyphenylacetic acid;    NO2HPA;    4-hydroxy-3-nitrophenylacetic acid;   

DOI  :  10.1016/S0014-5793(02)02659-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Human saliva contained 4-hydroxyphenylacetic acid (HPA) (2–10 μM) and nitrite (60–300 μM). HPA was nitrated to 4-hydroxy-3-nitrophenylacetic acid (NO₂HPA) when HPA and sodium nitrite were mixed at pH 1.0. NO₂HPA was also formed when saliva was incubated under acidic conditions. These results suggest that salivary HPA is nitrated to NO₂HPA when saliva is swallowed into the stomach.

【 授权许可】

Unknown