The plant Rad50–Mre11 protein complex

FEBS Letters

White, C.I¹  Daoudal-Cotterell, S¹  Gallego, M.E¹ 

[1] CNRS UMR6547-BIOMOVE, Université Blaise Pascal, 24, Avenue des Landais, 63177 Aubiere Cedex, France

关键词: Rad50;    Mre11;    Protein complex;    Plants;    DNA repair;    Recombination;   

DOI  :  10.1016/S0014-5793(02)02536-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The Rad50–Mre11–Xrs2/Nbs1 protein complex plays critical roles in cellular processes involving DNA ends. This complex is implicated in DNA recombination and replication, meiosis, telomere maintenance and cellular DNA damage responses. The Rad50 and Mre11 proteins are essential for viability in animals, although not in yeast. We have prepared antibodies to the Rad50 protein of the model plant Arabidopsis thaliana which recognize a 175 kDa protein in wild-type Arabidopsis protein extracts. Furthermore, we report here demonstration of the existence of the Rad50–Mre11 complex by co-immunoprecipitation of the Rad50 and Mre11 proteins from the plant cell extracts.

【 授权许可】

Unknown