Leptin directly stimulates thermogenesis in skeletal muscle

FEBS Letters

Solinas, Giovanni¹  Stock, Michael J³  Seydoux, Josiane²  Boss, Olivier¹  Dulloo, Abdul G¹  Montani, Jean-Pierre¹ 

[1] Institute of Physiology, Department of Medicine, University of Fribourg, Chemin du Musée 5, CH-1700 Fribourg, Switzerland;Department of Physiology, University of Geneva, Geneva, Switzerland;Department of Physiology, St George's Hospital Medical School, London, UK

关键词: Leptin;    Obesity;    Diabetes;    Thermogenesis;   

DOI  :  10.1016/S0014-5793(02)02449-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Using a method involving repeated oxygen uptake (MO₂) determinations in skeletal muscle ex vivo, the addition of leptin was found to increase MO₂ in soleus muscles from lean mice. These effects were found to be inhibited by phosphatidylinositol 3-kinase inhibitors, absent in muscles from obese Lepr^db mice which have the dysfunctional long form of leptin receptor, and blunted in muscles from diet-induced obese mice in the fed state but not during fasting. These findings indicate that leptin has direct thermogenic effects in skeletal muscle, and that these effects require both the long form of leptin receptors and phosphatidylinositol 3-kinase signalling.

【 授权许可】

Unknown