Genome‐wide detection and family clustering of ion channels

FEBS Letters

Ouzounis, Christos A¹  Harte, Rachel¹ 

[1] Computational Genomics Group, Research Programme, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK

关键词: Ion channels;    Genome analysis;    Sequence clustering;    Protein families;   

DOI  :  10.1016/S0014-5793(01)03254-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Ion channels represent an important class of molecules that can be classified into 13 distinct groups. We present a strategy using a ‘learning set’ of well-annotated ion channel sequences to detect homologues in 32 entire genome sequences from Archaea, Bacteria and Eukarya. A total of 299 putative ion channel protein sequences were detected, with significant variations across species. The clustering of these sequences reveals complex relationships between the different ion channel families.

【 授权许可】

Unknown