Cysteinyl‐tRNA formation and prolyl‐tRNA synthetase

FEBS Letters

Jacquin-Becker, Clarisse¹  Ruan, Benfang¹  Stathopoulos, Constantinos¹  Ambrogelly, Alexandre¹  Ahel, Ivan¹  Söll, Dieter¹ 

[1] Department of Molecular Biophysics and Biochemistry, Yale University, P.O. Box 208114, 266 Whitney Avenue, New Haven, CT 06520-8114, USA

关键词: Aminoacyl-tRNA synthetase;    Prolyl-tRNA synthetase;    Amino acid activation;    tRNA;    Translation;    AARS;    aminoacyl-tRNA synthetase;    Cys-tRNA;    cysteinyl-tRNA;    Pro-tRNA;    prolyl-tRNA;    CysRS;    cysteinyl-tRNA synthetase;    ProRS;    prolyl-tRNA synthetase;    AA-tRNA;    aminoacyl-tRNA;   

DOI  :  10.1016/S0014-5793(02)02331-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Aminoacyl-tRNA (AA-tRNA) formation is a key step in protein biosynthesis. This reaction is catalyzed with remarkable accuracy by the AA-tRNA synthetases, a family of 20 evolutionarily conserved enzymes. The lack of cysteinyl-tRNA (Cys-tRNA) synthetase in some archaea gave rise to the discovery of the archaeal prolyl-tRNA (Pro-tRNA) synthetase, an enzyme capable of synthesizing Pro-tRNA and Cys-tRNA. Here we review our current knowledge of this fascinating process.

【 授权许可】

Unknown