A tripeptide discriminator for stop codon recognition

FEBS Letters

Nakamura, Yoshikazu¹  Ito, Koichi¹ 

[1] Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8630, Japan

关键词: Translation termination;    Stop codon;    Tripeptide anticodon;    Polypeptide release factor;    tRNA mimic;    RF;    release factor;    PAT;    Pro–Ala–Thr;    SPF;    Ser–Pro–Phe;   

DOI  :  10.1016/S0014-5793(02)02330-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Only recently has it been established that a tripeptide in the bacterial release factors (RFs), RF1 and RF2, is responsible for the stop codon recognition. This functional mimic of the anticodon of tRNA is referred to as a tripeptide ‘anticodon’ or a tripeptide discriminator. Here we review the experimental background and process leading to this discovery, and strengthen functional evidence for the tripeptide determinant for deciphering stop codons in mRNAs in prokaryotes.

【 授权许可】

Unknown