The ENTH domain

FEBS Letters

Bateman, Alex³  Brunger, Axel T¹  De Camilli, Pietro¹  Chen, Hong¹  Panepucci, Ezequiel¹  Hyman, Joel² 

[1] Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA;Departments of Molecular and Cellular Physiology, Neurology and Neurological Sciences, and Stanford Synchrotron Radiation Laboratory, Stanford University, Stanford, CA 94305-5489, USA;The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK

关键词: VHS domain;    Ubiquitin;    Clathrin;    AP-2;    Endocytosis;    EH domain;   

DOI  :  10.1016/S0014-5793(01)03306-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The epsin NH2-terminal homology (ENTH) domain is a membrane interacting module composed by a superhelix of α-helices. It is present at the NH2-terminus of proteins that often contain consensus sequences for binding to clathrin coat components and their accessory factors, and therefore function as endocytic adaptors. ENTH domain containing proteins have additional roles in signaling and actin regulation and may have yet other actions in the nucleus. The ENTH domain is structurally similar to the VHS domain. These domains define two families of adaptor proteins which function in membrane traffic and whose interaction with membranes is regulated, in part, by phosphoinositides.

【 授权许可】

Unknown