FEBS Letters | |
Abrupt pubertal elevation of DNase I gene expression in human pituitary glands of both sexes | |
Ueki, Misuzu3  Nakajima, Tamiko2  Takeshita, Haruo2  Kishi, Koichiro2  Yasuda, Toshihiro3  Iida, Reiko1  Kaneko, Yasushi2  Mogi, Kouichi2  | |
[1] Department of Legal Medicine, Fukui Medical University, Matsuoka, Fukui 910-1193, Japan;Department of Legal Medicine, Gunma University School of Medicine, Showa-machi, Maebashi, Gunma 371-8511, Japan;Department of Biology, Fukui Medical University, Matsuoka, Fukui 910-1193, Japan | |
关键词: Age-dependent alteration; Deoxyribonuclease I; Gene expression; Pituitary gland; Puberty; Human; DAFO; dried agarose film overlay; DNase I; deoxyribonuclease I; IEF–PAGE; isoelectric focusing in a thin layer of polyacrylamide gel; LH-RH; luteinizing hormone-releasing hormone; SRED; single radial enzyme diffusion; | |
DOI : 10.1016/S0014-5793(01)03216-1 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Deoxyribonuclease I (DNase I) was confirmed to be expressed in the human pituitary gland, particularly the anterior lobe, at levels comparable to those in the pancreas. The DNase I activity and the amount of gene transcript present in the pituitary glands of individuals aged from 1 month to 89 years was significantly age-dependent, with an abrupt elevation after the neonatal and prepubertal periods irrespective of gender, followed by a gradual age-dependent decline in males and a marked reduction in females in their postreproductive period. This DNase I age dependence in the pituitary gland was not present in the pancreas and serum. These observations suggest that tissue-specific up-regulation of DNase I gene expression in the pituitary gland occur, possibly at the onset of puberty.
【 授权许可】
Unknown
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