S‐Adenosyl‐L‐homocysteine hydrolase is sequestered into actin rods in Dictyostelium discoideum spores

FEBS Letters

Mahadeo, Dana³  Sameshima, Masazumi¹  Sugo, Teruko²  Kishi, Yoshiro¹  Cotter, David³ 

[1] Electron Microscopy Center, The Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8613, Japan;Division of Cell and Molecular Medicine, Center for Molecular Medicine, Jichi Medical School, Yakushiji 3311-1, Tochigi 329-0498, Japan;Department of Biological Sciences, University of Windsor, 401 Sunset Avenue, Windsor, ON, Canada N9B 3P4

关键词: S-Adenosyl-L-homocysteine hydrolase;    Actin;    Antivirus;    Dictyostelium;   

DOI  :  10.1016/S0014-5793(01)03105-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Here we show evidence that S-adenosyl-L-homocysteine hydrolase (SAHH) is linked to the actin cytoskeleton. Actin rods formed in Dictyostelium discoideum spores during the final stage of development are structurally composed of novel bundles of actin filaments. SAHH only accumulates with actin at this stage of development in the life cycle of D. discoideum. Recently SAHH is believed to be a target for antiviral chemotherapy and the suppression of T cells. Our finding may contribute to designing novel antiviral and immunosuppressive drugs.

【 授权许可】

Unknown