Characterization of acute somatosensory pain transmission in P/Q‐type Ca2+ channel mutant mice, leaner

FEBS Letters

Tanabe, Tsutomu¹  Ogasawara, Miki¹  Hu, Qiuping¹  Kurihara, Takashi¹ 

[1] Department of Pharmacology and Neurobiology, Graduate School of Medicine, Tokyo Medical and Dental University, CREST, Japan Science and Technology Corporation, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan

关键词: Voltage-dependent calcium channel;    P/Q-type calcium channel;    Nociception;    Pain;    Dorsal root potential;    Spinal cord;    ACSF;    artificial cerebrospinal fluid;    CAP;    compound action potential;    CV;    conduction velocity;    DRP;    dorsal root potential;    HVA;    high-voltage-activated;    LVA;    low-voltage-activated;    MSR;    monosynaptic reflex;    sVRP;    slow ventral root potential;    VDCC;    voltage-dependent Ca2+ channel;   

DOI  :  10.1016/S0014-5793(01)03052-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

To study the role of the Ca_v2.1/α_1A (P/Q-type) Ca²⁺ channel in somatosensory pain processing, behavioral and electrophysiological studies were conducted using the leaner (tg^la/tg^la ) mouse. Behavioral analyses in tg^la/tg^la revealed reduced responses to mechanical stimuli, and enhanced responses to heat stimuli. Electrophysiological analyses showed that tg^la/tg^la had a significantly reduced ability to evoke dorsal root potentials, suggesting a functional deficit in the spinal dorsal horn local circuitry responsible for presynaptic inhibition of primary sensory fibers. These results suggest the critical importance of the P/Q-type channel in modulation of acute somatosensory pain transmission in spinal cord.

【 授权许可】

Unknown