FEBS Letters | |
Characterization of acute somatosensory pain transmission in P/Q‐type Ca2+ channel mutant mice, leaner | |
Tanabe, Tsutomu1  Ogasawara, Miki1  Hu, Qiuping1  Kurihara, Takashi1  | |
[1] Department of Pharmacology and Neurobiology, Graduate School of Medicine, Tokyo Medical and Dental University, CREST, Japan Science and Technology Corporation, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan | |
关键词: Voltage-dependent calcium channel; P/Q-type calcium channel; Nociception; Pain; Dorsal root potential; Spinal cord; ACSF; artificial cerebrospinal fluid; CAP; compound action potential; CV; conduction velocity; DRP; dorsal root potential; HVA; high-voltage-activated; LVA; low-voltage-activated; MSR; monosynaptic reflex; sVRP; slow ventral root potential; VDCC; voltage-dependent Ca2+ channel; | |
DOI : 10.1016/S0014-5793(01)03052-6 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
To study the role of the Cav2.1/α1A (P/Q-type) Ca2+ channel in somatosensory pain processing, behavioral and electrophysiological studies were conducted using the leaner (tgla/tgla ) mouse. Behavioral analyses in tgla/tgla revealed reduced responses to mechanical stimuli, and enhanced responses to heat stimuli. Electrophysiological analyses showed that tgla/tgla had a significantly reduced ability to evoke dorsal root potentials, suggesting a functional deficit in the spinal dorsal horn local circuitry responsible for presynaptic inhibition of primary sensory fibers. These results suggest the critical importance of the P/Q-type channel in modulation of acute somatosensory pain transmission in spinal cord.
【 授权许可】
Unknown
【 预 览 】
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