In silico screening for tumour‐specific expressed sequences in human genome

FEBS Letters

Ivanov, D.V.²  Kozlov, A.P.¹  Yankovsky, N.K.²  Lobashev, A.V.²  Baranova, A.V.²  Krukovskaya, L.L.¹ 

[1] Biomedical Center, Research Institute of Pure Biochemicals, 7 Pudozhskaya Str, St. Petersburg 197110, Russia;Vavilov Institute of General Genetics, 3 Gubkina Str., Moscow 119991, Russia

关键词: Computer-based differential display;    Cancer;    Gene expression;   

DOI  :  10.1016/S0014-5793(01)03028-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of tumours versus a set of normal tissues. A list of EST clusters highly represented in tumours and rarely observed in normal tissues has been developed as a resulting output file of the program. These differentially expressed EST clusters (genes) can be useful for developing new tumour markers and prognostic indicators for a wide set of human malignancies. Tumour-specific protein-coding genes may be considered a manifestation of tumour-specific gene expression.

【 授权许可】

Unknown