Cellular strategies for proteolytic targeting during migration and invasion

FEBS Letters

Ellis, Vincent¹  Murphy, Gillian¹ 

[1] School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK

关键词: Serine proteinase;    Metalloproteinase;    Cell membrane;    Extracellular matrix;    Migration;   

DOI  :  10.1016/S0014-5793(01)02845-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Cell migration over or through the extracellular matrix (ECM) is an integral feature of both physiological and pathological processes. Regulation of the changing cell–ECM interactions involved can be effected by proteolysis and requires strict spatial and temporal targeting of proteinase activity. The versatile use of different proteinase systems, with a variety of localisation mechanisms and cleavage targets, is being revealed by a plethora of studies using in vitro models. This mini review reflects the status of our knowledge of strategies for the localisation of proteolytic activity effected during cell migration.

【 授权许可】

Unknown