A plant Shaker‐like K+ channel switches between two distinct gating modes resulting in either inward‐rectifying or ‘leak’ current

FEBS Letters

Dreyer, Ingo¹  Michard, Erwan¹  Lacombe, Benoı̂t¹  Thibaud, Jean-Baptiste¹ 

[1] Laboratoire de Biochimie et Physiologie Moléculaire des Plantes, UMR 5004, Agro-M/CNRS/INRA/UM2, Place Viala, 34060 Montpellier, Cedex 1, France

关键词: Potassium channel;    Voltage-gating;    Post-translational modification;    Patch-clamp;   

DOI  :  10.1016/S0014-5793(01)02832-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Among the Shaker-like plant potassium channels, AKT2 is remarkable because it mediates both instantaneous ‘leak-like’ and time-dependent hyperpolarisation-activated currents. This unique gating behaviour has been analysed in Xenopus oocytes and in COS and Chinese hamster ovary cells. Whole-cell and single-channel data show that (i) AKT2 channels display two distinct gating modes, (ii) the gating of a given AKT2 channel can change from one mode to the other and (iii) this conversion is under the control of post-translational factor(s). This behaviour is strongly reminiscent of that of the KCNK2 channel, recently reported to be controlled by its phosphorylation state.

【 授权许可】

Unknown