The Candida albicans Na+/H+ antiporter exports potassium and rubidium

FEBS Letters

Potier, Serge¹  Sychrová, Hana²  Kinclová, Olga² 

[1] Laboratory of Microbiology and Genetics, UPRES A-7010-CNRS, Université Louis Pasteur, 28 rue Goethe, 67083 Strasbourg, France;Department of Membrane Transport, Institute of Physiology CzAcadSci, Videnska 1083, 14220 Prague 4, Czech Republic

关键词: Na+/H+ antiporter;    Potassium efflux;    Salt tolerance;    Candida albicans;   

DOI  :  10.1016/S0014-5793(01)02755-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The Candida albicans Cnh1p belongs to the family of Na⁺/H⁺ antiporters (TC 2.A.36) but it transports besides toxic sodium and lithium also rubidium and potassium. Upon heterologous expression in a Saccharomyces cerevisiae salt-sensitive strain, the Cnh1p is targeted to the plasma membrane and its transport activity results in increased tolerance of cells to external alkali metal cations. The cation efflux activity of Cnh1p in S. cerevisiae depends on the gradient of protons across the plasma membrane, and a Cnh1p-mediated K⁺ efflux is involved in a cell response to sudden rise of cytoplasmic pH.

【 授权许可】

Unknown