Coordination between transcription and pre‐mRNA processing

FEBS Letters

Srebrow, A.²  Melen, G.²  Nogués, G.²  Cramer, P.¹  de la Mata, M.²  Kadener, S.²  Werbajh, S.²  Kornblihtt, A.R.² 

[1] Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA;Laboratorio de Fisiologı́a y Biologı́a Molecular, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, C1428EHA Buenos Aires, Argentina

关键词: RNA polymerase II;    mRNA processing;    Carboxy-terminal domain;    Coupling;   

DOI  :  10.1016/S0014-5793(01)02485-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A large body of work has proved that transcription by RNA polymerase II and pre-mRNA processing are coordinated events within the cell nucleus. Capping, splicing and polyadenylation occur while transcription proceeds, suggesting that RNA polymerase II plays a role in the regulation of these events. The presence and degree of phosphorylation of the carboxy-terminal domain of RNA polymerase II large subunit is important for functioning of the capping enzymes, the assembly of spliceosomes and the binding of the cleavage/polyadenylation complex. Nuclear architecture and gene promoter structure have also been shown to play key roles in coupling between transcription and splicing.

【 授权许可】

Unknown