A role for Cajal bodies in assembly of the nuclear transcription machinery

FEBS Letters

Gall, Joseph G¹ 

[1] Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210-3301, USA

关键词: Cajal body;    Nucleus;    Oocyte;    RNA polymerase;    Transcription;   

DOI  :  10.1016/S0014-5793(01)02461-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Cajal bodies (CBs) are small nuclear organelles that contain the three eukaryotic RNA polymerases and a variety of factors involved in transcription and processing of all types of RNA. A number of these factors, as well as subunits of polymerase (pol) II itself, are rapidly and specifically targeted to CBs when injected into the cell. It is suggested that pol I, pol II, and pol III transcription and processing complexes are preassembled in the CBs before transport to the sites of transcription on the chromosomes and in the nucleoli.

【 授权许可】

Unknown