P2 purinergic receptors of human eosinophils: characterization and coupling to oxygen radical production

FEBS Letters

Idzko, Marco³  Virchow, Christian³  Di Virgilio, Francesco¹  Luttmann, Werner³  Chiozzi, Paola¹  Ferrari, Davide¹  Norgauer, Johannes²  Dichmann, Stefan²  Purlis, Daniela² 

[1]Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, via L. Borsari 46, I-44100 Ferrara, Italy

[2]Department of Dermatology, University of Freiburg, Hugstellter-str. 55, Freiburg D-79106, Germany

[3]Department of Pneumology, University of Freiburg, Hugstellter-str. 55, Freiburg D-79106, Germany

关键词: Inflammation;    Eosinophil;    Extracellular ATP;    Purinoceptor;    Oxygen radical;   

DOI  :  10.1016/S0014-5793(00)02306-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Extracellular nucleotides elicit multiple responses in eosinophils but no information on expression of purinergic receptors in these cells is available so far. In the present study we show that human eosinophils express the following P2Y and P2X subtypes: P2Y₁, P2Y₂, P2Y₄, P2Y₆, P2Y₁₁, and P2X₁, P2X₄, P2X₇, whose stimulation results in intracellular Ca²⁺ increase and production of large amounts of reactive oxygen intermediates. These events are stimulated or inhibited, respectively, by P2 receptor agonists or antagonists.

【 授权许可】

Unknown