MAIL, a novel nuclear IκB protein that potentiates LPS‐induced IL‐6 production

FEBS Letters

Saito, Masayuki¹  Kitamura, Hiroshi¹  Morimatsu, Masami²  Okita, Keisuke¹  Kanehira, Katsushi¹ 

[1] Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan;Department of Veterinary Physiology, Faculty of Agriculture, Iwate University, Morioka 020-8550, Japan

关键词: Lipopolysaccharide;    Interleukin 6;    Bcl3;    IκB;    Ankyrin-repeat;    Inflammation;    LPS;    lipopolysaccharide;    IL;    interleukin;    AA;    amino acids;   

DOI  :  10.1016/S0014-5793(00)02185-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have identified and characterized a novel member of the ankyrin-repeat family named ‘molecule possessing ankyrin-repeats induced by lipopolysaccharide’ (MAIL). The C-terminal portion of MAIL shared high sequence homology with the IκB family. Intraperitoneal injection of lipopolysaccharide (LPS) into mice rapidly (<0.5 h) induced MAIL mRNA in various tissues, particularly in the spleen, lymph node, and lung. Ectopically expressed MAIL was localized in the nucleus, and remarkably potentiated the LPS-induced mRNA expression and secretion of interleukin (IL)-6 in Swiss 3T3 cells. These findings indicate that MAIL is one of the nuclear IκB proteins and an activator of IL-6 production.

【 授权许可】

Unknown