Cleavage of yeast tRNAPhe with complementary oligonucleotide conjugated to a small ribonuclease mimic

FEBS Letters

Sil'nikov, V.N.¹  Beloglazova, N.G.¹  Zenkova, M.A.¹  Vlassov, V.V.¹ 

[1] Institute of Bioorganic Chemistry, Siberian Branch of Russian Academy of Sciences, 8 Lavrentiev Avenue, Novosibirsk 630090, Russia

关键词: Antisense oligonucleotide;    Ribonuclease mimic;    tRNA;    RNA cleavage;   

DOI  :  10.1016/S0014-5793(00)02029-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

An oligonucleotide conjugate bearing a chemical construct mimicking the catalytic center of ribonuclease A has been designed and studied. The conjugate efficiently cleaves yeast tRNA^Phe at a single site adjacent to the target complementary sequence.

【 授权许可】

Unknown