期刊论文详细信息
FEBS Letters | |
Cleavage of yeast tRNAPhe with complementary oligonucleotide conjugated to a small ribonuclease mimic | |
Sil'nikov, V.N.1  Beloglazova, N.G.1  Zenkova, M.A.1  Vlassov, V.V.1  | |
[1] Institute of Bioorganic Chemistry, Siberian Branch of Russian Academy of Sciences, 8 Lavrentiev Avenue, Novosibirsk 630090, Russia | |
关键词: Antisense oligonucleotide; Ribonuclease mimic; tRNA; RNA cleavage; | |
DOI : 10.1016/S0014-5793(00)02029-9 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
An oligonucleotide conjugate bearing a chemical construct mimicking the catalytic center of ribonuclease A has been designed and studied. The conjugate efficiently cleaves yeast tRNAPhe at a single site adjacent to the target complementary sequence.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912020309813ZK.pdf | 260KB | download |