Molecular identification of a glucose transporter from fish muscle 1

FEBS Letters

Capilla, Encarnación¹  Gutiérrez, Joaquim¹  Planas, Josep V.¹ 

[1] Departament de Fisiologia, Facultat de Biologia, Universitat de Barcelona, Av. Diagonal 645, 08028 Barcelona, Spain

关键词: Glucose transporter;    Muscle;    Fish;    Trout;    RACE;    rapid amplification of cDNA ends;    RT-PCR;    reverse transcription-polymerase chain reaction;    TM;    transmembrane domain;   

DOI  :  10.1016/S0014-5793(00)02020-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In mammals and birds, several isoforms of facilitative glucose transporters have been identified (GLUT1–4), but no information is available regarding the molecules involved in glucose transport in other vertebrates. Here we report the cloning of a GLUT molecule from fish muscle with high sequence homology to GLUT4 and containing features characteristic of a functional GLUT. Fish GLUT is expressed predominantly in skeletal muscle, kidney and gill, which are tissues with known high glucose utilization. These results indicate that fish GLUT is structurally, and perhaps functionally, similar to the other known GLUTs expressed in muscle in mammalian and avian species.

【 授权许可】

Unknown