Geranylgeranylated RhoB is sufficient to mediate tissue‐specific suppression of Akt kinase activity by farnesyltransferase inhibitors

FEBS Letters

Liu, Ai-xue¹  Prendergast, George C.¹ 

[1] The Wistar Institute, Philadelphia, PA 19104, USA

关键词: Ras;    Rho;    Farnesyltransferase inhibitor;    Akt;    Prk;    Signal transduction;    Apoptosis;   

DOI  :  10.1016/S0014-5793(00)02003-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Farnesyltransferase inhibitors (FTIs) induce apoptosis by elevating the levels of geranylgeranylated RhoB (RhoB-GG) in cells. However, the mechanism by which RhoB-GG acts is unclear. Here we report that RhoB-GG is sufficient to mediate the suppressive effects of FTIs on the activity of the survival kinase Akt-1 in epithelial cells. This mechanism is tissue-specific insofar as it does not operate in fibroblasts. We discuss how the cell survival functions of RhoB and Akt may be linked biochemically in certain cell types.

【 授权许可】

Unknown