The S. pombe sep1 gene encodes a nuclear protein that is required for periodic expression of the cdc15 gene

FEBS Letters

Simanis, Viesturs²  Salimova, Ekaterina²  Sipiczki, Matthias¹  Zilahi, Erika¹ 

[1] Department of Genetics, University of Debrecen, P.O. Box 56, H-4010 Debrecen, Hungary;Cell Cycle Control Laboratory, Swiss Institute for Experimental Cancer Research (ISREC), 1066 Epalinges, Switzerland

关键词: Cytokinesis;    Septum formation;    Transcription;    cdc15;    Schizosaccharomyces pombe;   

DOI  :  10.1016/S0014-5793(00)01990-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The Schizosaccharomyces pombe sep1 gene encodes a putative transcription factor that is required for cell separation. Among the genes required for septum formation and cytokinesis in fission yeast examined to date, the only one whose mRNA fluctuates significantly during the cell cycle is cdc15. In this study we have examined cdc15 mRNA levels in sep1 mutant and null backgrounds and have found that sep1p function is required for periodic accumulation of cdc15 mRNA. We have also localised sep1p and find that it is a nuclear protein, consistent with its proposed role as a transcription factor.

【 授权许可】

Unknown