STAM2, a new member of the STAM family, binding to the Janus kinases

FEBS Letters

Endo, Kazuhiro²  Kikuchi, Kazu²  O'Shea, John J.¹  Tanaka, Nobuyuki²  Takeshita, Toshikazu²  Sugamura, Kazuo²  Chen, Min¹  Asao, Hironobu²  Kasai, Hirotake²  Sasaki, Yoshiteru²  Yamada, Mitsuhiro² 

[1] Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Health, Bethesda, MD 20892, USA;Department of Microbiology and Immunology, Tohoku University School of Medicine, Seiryo-machi 2-1, Aoba-ku, Sendai 980-8575, Japan

关键词: IL-2;    GM-CSF;    Signal transduction;    Tyrosine kinase;    Jak;    Janus kinase;    SH3;    Src homology 3;    ITAM;    immunoreceptor tyrosine-based activation motif;    IL-;    interleukin;    GM-CSF;    granulocyte/macrophage colony stimulating factor;    EGF;    epidermal cell growth factor;    PDGF;    platelet-derived growth factor;    Ab;    antibody;    mAb;    monoclonal antibody;   

DOI  :  10.1016/S0014-5793(00)01760-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We here cloned a cDNA encoding STAM2, a new member of the STAM family, which contains an SH3 domain and ITAM. STAM2 like STAM1 is associated with Jak2 and Jak3, and involved in the signaling for DNA synthesis and c-myc induction mediated by IL-2 and GM-CSF. Co-expression of the SH3 deletion mutants of STAM1 and STAM2 induces an additive effect on suppressing DNA synthesis upon stimulation with IL-2 and GM-CSF, suggesting that STAM1 and STAM2 exhibit compensatory effects on the signaling pathways downstream of Jak2 and Jak3 upon stimulation with GM-SCF and IL-2, respectively.

【 授权许可】

Unknown