Urokinase‐type plasminogen activator up‐regulates the expression of its cellular receptor

FEBS Letters

Montuori, Nunzia²  Rossi, Guido²  Salzano, Salvatore¹  Ragno, Pia¹ 

[1] Centro di Endocrinologia ed Oncologia Sperimentale (CEOS), Consiglio Nazionale delle Ricerche, via Pansini 5, I-80131 Naples, Italy;Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli, via Pansini 5, I-80131 Naples, Italy

关键词: Urokinase;    Urokinase receptor;    Plasminogen activation;   

DOI  :  10.1016/S0014-5793(00)01713-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The expression of the receptor for the urokinase-type plasminogen activator (uPAR) can be regulated by several hormones, cytokines, tumor promoters, etc. Recently, it has been reported that uPAR is capable of transducing signals, even though it is lacking a transmembrane domain and a cytoplasmatic tail. We now report that uPAR cell surface expression can be positively regulated by its ligand, uPA, in thyroid cells. The effect of uPA is independent of its proteolytic activity, since inactivated uPA or its aminoterminal fragment have the same effects of the active enzyme. The increase of uPAR on the cell surface correlates with an increase of specific uPAR mRNA. Finally, uPA up-regulates uPAR expression also in other cell lines of different type and origin, thus suggesting that the regulatory role of uPA on uPAR expression is not restricted to thyroid cells, but it occurs in different tissues, both normal and tumoral.

【 授权许可】

Unknown