Regulating the cellular economy of supply and demand

FEBS Letters

Cornish-Bowden, Athel¹  Hofmeyr, Jan-Hendrik S.² 

[1] CNRS-BIP, 31 chemin Joseph-Aiguier, B.P. 71, 13402 Marseille Cedex 20, France;Department of Biochemistry, University of Stellenbosch, Private Bag X1, Matieland 7602, South Africa

关键词: Supply–demand analysis;    Metabolic regulation;    Control analysis;    Feedback inhibition;   

DOI  :  10.1016/S0014-5793(00)01668-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Cellular metabolism is a molecular economy that is functionally organised into supply and demand blocks linked by metabolic products and cofactor cycles. Supply–demand analysis allows the behaviour, control and regulation of metabolism as a whole to be understood quantitatively in terms of the elasticities of supply and demand, which are experimentally measurable properties of the individual blocks. The kinetic and thermodynamic aspects of regulation are clearly distinguished. One important result is the demonstration that when flux is controlled by one block, the other block determines to which degree the concentration of the linking metabolite is homeostatically maintained.

【 授权许可】

Unknown